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Article Dans Une Revue Clinical Science Année : 2020

SARS-CoV2 may evade innate immune response, causing uncontrolled neutrophil extracellular traps formation and multi-organ failure

Résumé

We demonstrate that the general clinical conditions, risk factors and numerous pathological and biological features of COVID-19 are analogous with various disorders caused by the uncontrolled formation of neutrophil extracellular traps and their by-products. Given the rapid evolution of this disease’s symptoms and its lethality, we hypothesize that SARS-CoV2 evades innate immune response causing COVID-19 progresses under just such an amplifier loop, leading to a massive, uncontrolled inflammation process. This work allows us to propose new strategies for treating the pandemic.
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Origine : Publication financée par une institution

Dates et versions

hal-03610935 , version 1 (03-06-2022)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Alain Thierry, Benoit Roch. SARS-CoV2 may evade innate immune response, causing uncontrolled neutrophil extracellular traps formation and multi-organ failure. Clinical Science, 2020, 134 (12), pp.1295-1300. ⟨10.1042/CS20200531⟩. ⟨hal-03610935⟩
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