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Article Dans Une Revue Allergy Année : 2020

A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2

1 Hospital Sant Joan de Déu [Barcelona]
2 Institut de Recerca Pediàtrica Hospital Sant Joan de Déu [Barcelona, Spain]
3 University of Pisa - Università di Pisa
4 Sechenov First Moscow State Medical University
5 UniFI - Università degli Studi di Firenze = University of Florence = Université de Florence
6 Transilvania University of Brasov
7 Swiss Institute of Allergy and Asthma Research (SIAF)
8 Hospital CUF Descobertas
9 CINTESIS - Center of Research in Health Technologies and Information Systems
10 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
11 IMIM-Hospital del Mar
12 UPF - Universitat Pompeu Fabra [Barcelona]
13 UNIVR - Università degli studi di Verona = University of Verona
14 University of Kirikkale
15 Kanuni Sultan Suleyman Research and Training Hospital [Istanbul]
16 Fondazione Policlinico Universitario Agostino Gemelli IRCCS
17 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
18 BIH - Berlin Institute of Health
19 MACVIA-LR - Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon
20 Medizinische Universität Wien = Medical University of Vienna
21 NOVA - Universidade Nova de Lisboa = NOVA University Lisbon
22 Hospital Universitario Marqués de Valdecilla [Santander]
23 Skane University Hospital [Lund]
24 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic]
25 UMCG - University Medical Center Groningen [Groningen]
26 IBIMA Plataforma BIONAND - Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina = Biomedical Research Institute of Málaga and Nanomedicine Platform
27 Hospital Regional Universitario de Málaga = Regional University Hospital of Malaga [Spain]
28 National Network ARADyAL - Allergy Unit [Malaga, Spain]
29 SickKids - The Hospital for sick children [Toronto]
30 University of Toronto
31 CK-CARE, ZAUM - Center of Allergy & Environment
32 HMGU - Helmholtz Zentrum München = German Research Center for Environmental Health
33 Amsterdam UMC - Amsterdam University Medical Center
34 Zhongnan Hospital
35 CHL - Centre Hospitalier de Luxembourg [Luxembourg]
36 NHLI - National Heart and Lung Institute [London]
37 UWr - University of Wrocław [Poland]
39 “Agios Georgios” General Hospital of Chania
40 Center for Rhinology and Allergology = Zentrum für Rhinologie und Allergologie
41 Hospital Universitario 12 de Octubre [Madrid]
42 Sean N. Parker Center for Allergy and Asthma Research [Stanford]
43 Monash University [Melbourne]
44 The Alfred Hospital
45 UCC - University College Cork
46 Philipps Universität Marburg = Philipps University of Marburg
47 UJ - Uniwersytet Jagielloński w Krakowie = Jagiellonian University
48 Edin. - University of Edinburgh
49 SIAF - Swiss Institute of Allergy and Asthma Research
50 CK-CARE - Christine Kühne – Centre for Allergy Research and Education
51 Yong Loo Lin School of Medicine [Singapore]
52 Beijing Tongren Hospital
53 CNB-CSIC - Centro Nacional de Biotecnología [Madrid]
54 McMaster Immunology Research Centre [Ontario, Canada]
55 UFV - Université Francisco de Vitoria = Universidad Francisco de Vitoria
Ioana Agache
Ahmet Kursat Azkur
Dilek Azkur
Ya-Dong Gao
  • Fonction : Auteur
Marek Jutel
Liam O'Mahony
Jürgen Schwarze
Luo Zhang


In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date, it has resulted in ~9 million confirmed cases and caused almost 500 000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socioeconomic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a "cytokine storm" leading to acute respiratory distress syndrome, endothelitis, thromboembolic complications, and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19, and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development, and epidemiology. A total of 150 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease.

Dates et versions

hal-03609089 , version 1 (15-03-2022)



Carmen Riggioni, Pasquale Comberiati, Mattia Giovannini, Ioana Agache, Mübeccel Akdis, et al.. A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2. Allergy, 2020, 75 (10), pp.2503-2541. ⟨10.1111/all.14449⟩. ⟨hal-03609089⟩
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