SMPD1 variants do not have a major role in rapid eye movement sleep behavior disorder - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Neurobiology of Aging Année : 2020

SMPD1 variants do not have a major role in rapid eye movement sleep behavior disorder

(1, 2) , (1) , (1) , (1) , (3) , (3) , (1) , (4) , (5) , (6, 7) , (7, 8) , (7, 6) , (9, 10) , (11, 12) , (11) , (13) , (14) , (14) , (14) , (15) , (15) , (16) , (16) , (17, 18) , (17, 18) , (19) , (19) , (20, 21) , (20, 22) , (16, 20) , (23, 24) , (25) , (26) , (27) , (28) , (28) , (29) , (30) , (1, 31) , (32, 1) , (32, 1)
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
Karl Heilbron
  • Fonction : Auteur
Paul Cannon
  • Fonction : Auteur
Ambra Stefani
Michela Figorilli
Monica Puligheddu
Femke Dijkstra
Mineke Viaene

Résumé

Mutations in the sphingomyelin phosphodiesterase 1 (SMPD1) gene were reported to be associated with Parkinson's disease and dementia with Lewy bodies. In the current study, we aimed to evaluate the role of SMPD1 variants in isolated rapid eye movement sleep behavior disorder (iRBD). SMPD1 and its untranslated regions were sequenced using targeted next-generation sequencing in 959 iRBD patients and 1287 controls from European descent. Our study reports no statistically significant association of SMPD1 variants and iRBD. It is hence unlikely that SMPD1 plays a major role in iRBD.

Dates et versions

hal-03574835 , version 1 (15-02-2022)

Identifiants

Citer

Uladzislau Rudakou, Naomi Futhey, Lynne Krohn, Jennifer Ruskey, Karl Heilbron, et al.. SMPD1 variants do not have a major role in rapid eye movement sleep behavior disorder. Neurobiology of Aging, 2020, 93, pp.142.e5-142.e7. ⟨10.1016/j.neurobiolaging.2020.04.005⟩. ⟨hal-03574835⟩
14 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook Twitter LinkedIn More