Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis

Mesenchymal stem cells (MSCs) are a unique population of adult stem cells that can differentiate into many cell types. As such, MSCs represent an interesting source of stem cells for use in the clinical treatment of a variety of disorders involving tissue regeneration. It is therefore crucial to investigate further, whether MSCs from patients with bone or cartilage diseases are able to provide iPSCs lines with efficient differentiation ability into MSC derivatives. For this purpose, we derived 3 stable iPSC lines from the MSCs of 3 elderly patients with osteoarthritis (OA) able to re-differentiate into MSC to make bone, cartilage and adipose tissue.

Domaines

Rhumatologie et système ostéo-articulaire

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StemCellRes-2020-Lydiane.pdf (1.17 Mo)

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https://hal.umontpellier.fr/hal-02961555

Soumis le : jeudi 8 octobre 2020-15:17:44

Dernière modification le : vendredi 9 septembre 2022-10:20:08

Archivage à long terme le : samedi 9 janvier 2021-18:46:25

Dates et versions

hal-02961555 , version 1 (08-10-2020)

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Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

HAL Id : hal-02961555 , version 1
DOI : 10.1016/j.scr.2020.101721
PUBMED : 32200258

Citer

Lydiane Pichard, Jean-Marc Brondello, Fabienne Becker, Romain Desprat, Frédéric de Ceuninck, et al.. Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis. Stem Cell Research, 2020, 44, pp.101721. ⟨10.1016/j.scr.2020.101721⟩. ⟨hal-02961555⟩

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