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Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis Lydiane Pichard 1805340-0 Jean-Marc Brondello f5200bda5a6f5ca04469928b91626322 inserm.fr jean-marc-brondello 21358 9477-21358 http://www.researcherid.com/rid/https://publons.com/researcher/1745930/jean-marc-brondello/ https://orcid.org/0000-0001-5991-3945 https://www.idref.fr/169662284 Fabienne Becker 612971-0 Romain Desprat 590311-0 Frédéric de Ceuninck 2041372-0 Philippe Pastoureau 2041373-0 Danièle Noël 9b8074066e93732b9b0c4201185516c2 inserm.fr daniele-noel 21357 2741-21357 https://orcid.org/0000-0002-3498-3776 https://www.idref.fr/166770000 Christian Jorgensen fc0d035a3d3d9ab91e2900d48d2b8f1b inserm.fr 756860 159170-756860 https://orcid.org/0000-0001-6947-8094 https://www.idref.fr/081434677 https://viaf.org/viaf/294734983 http://isni.org/isni/0000000399637249 Jean-Marc Lemaitre 53ce6bfe22ffd005fcff2de055a2f63c inserm.fr 1033305 704133-1033305 https://orcid.org/0000-0002-6492-5219 Anthony Herrada fcb22fb3703cf470da2926a2fd72f58a unimes.fr 2020-10-08 15:17:44 2024-09-11 20:12:11 2020-10-09 14:08:29 2020-04 2020-10-08 contributor Anthony Herrada fcb22fb3703cf470da2926a2fd72f58a unimes.fr CCSD hal-02961555 https://hal.umontpellier.fr/hal-02961555 pichard:hal-02961555 <i>Stem Cell Research</i>, 2020, 44, pp.101721. <a target="_blank" href="https://dx.doi.org/10.1016/j.scr.2020.101721">⟨10.1016/j.scr.2020.101721⟩</a> Stem Cell Research, 2020, 44, pp.101721. ⟨10.1016/j.scr.2020.101721⟩ CC BY-NC-ND 4.0 - Attribution - Non-commercial use - No Derivative Works Biologie-Santé Université de Montpellier ANR Université de Montpellier (2015-2021) International No Yes Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis Lydiane Pichard 1805340-0 Jean-Marc Brondello f5200bda5a6f5ca04469928b91626322 inserm.fr jean-marc-brondello 21358 9477-21358 http://www.researcherid.com/rid/https://publons.com/researcher/1745930/jean-marc-brondello/ https://orcid.org/0000-0001-5991-3945 https://www.idref.fr/169662284 Fabienne Becker 612971-0 Romain Desprat 590311-0 Frédéric de Ceuninck 2041372-0 Philippe Pastoureau 2041373-0 Danièle Noël 9b8074066e93732b9b0c4201185516c2 inserm.fr daniele-noel 21357 2741-21357 https://orcid.org/0000-0002-3498-3776 https://www.idref.fr/166770000 Christian Jorgensen fc0d035a3d3d9ab91e2900d48d2b8f1b inserm.fr 756860 159170-756860 https://orcid.org/0000-0001-6947-8094 https://www.idref.fr/081434677 https://viaf.org/viaf/294734983 http://isni.org/isni/0000000399637249 Jean-Marc Lemaitre 53ce6bfe22ffd005fcff2de055a2f63c inserm.fr 1033305 704133-1033305 https://orcid.org/0000-0002-6492-5219 104497 1876-7753 Stem Cell Research Elsevier 44 101721 2020-04 10.1016/j.scr.2020.101721 32200258 English Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system Journal articles Journal articles Journal articles

Mesenchymal stem cells (MSCs) are a unique population of adult stem cells that can differentiate into many cell types. As such, MSCs represent an interesting source of stem cells for use in the clinical treatment of a variety of disorders involving tissue regeneration. It is therefore crucial to investigate further, whether MSCs from patients with bone or cartilage diseases are able to provide iPSCs lines with efficient differentiation ability into MSC derivatives. For this purpose, we derived 3 stable iPSC lines from the MSCs of 3 elderly patients with osteoarthritis (OA) able to re-differentiate into MSC to make bone, cartilage and adipose tissue.

000000009961060X https://ror.org/04m6sq715 Centre Hospitalier Régional Universitaire [Montpellier] CHRU Montpellier

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https://www.chu-montpellier.fr/fr/ 0000000120970141 https://ror.org/051escj72 Université de Montpellier UM 2021-12-31

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http://www.umontpellier.fr/ 200716494C https://ror.org/00b8mh310 Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB) 2021-12-31

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