Synthetic Strategies for Dinucleotides Synthesis

Abstract : Dinucleoside 5',5'-polyphosphates (DNPs) are endogenous substances that play important intra- and extracellular roles in various biological processes, such as cell proliferation, regulation of enzymes, neurotransmission, platelet disaggregation and modulation of vascular tone. Various methodologies have been developed over the past fifty years to access these compounds, involving enzymatic processes or chemical procedures based either on P(III) or P(V) chemistry. Both solution-phase and solid-support strategies have been developed and are reported here. Recently, green chemistry approaches have emerged, offering attracting alternatives. This review outlines the main synthetic pathways for the preparation of dinucleoside 5',5'-polyphosphates, focusing on pharmacologically relevant compounds, and highlighting recent advances.
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Soumis le : vendredi 20 décembre 2019 - 13:06:04
Dernière modification le : mercredi 8 janvier 2020 - 02:01:47


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Lucie Appy, Crystalle Chardet, Suzanne Peyrottes, Béatrice Roy. Synthetic Strategies for Dinucleotides Synthesis. Molecules, MDPI, 2019, 24 (23), pp.4334. ⟨10.3390/molecules24234334⟩. ⟨hal-02421271⟩



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