Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

Abstract : Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential 'on-off' switch of pDC activity with therapeutic potential.
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https://hal.umontpellier.fr/hal-02075366
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Nikaïa Smith, Nicolas Pietrancosta, Sophia Davidson, Jacques Dutrieux, Lise Chauveau, et al.. Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement. Nature Communications, Nature Publishing Group, 2017, 8, pp.14253. ⟨10.1038/ncomms14253⟩. ⟨hal-02075366⟩

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