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Article Dans Une Revue Nature Communications Année : 2017

Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

Pasquale Cutolo
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Thierry Durroux
Olivier Schwartz
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Andreas Wack
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Résumé

Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential 'on-off' switch of pDC activity with therapeutic potential.
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hal-02075366 , version 1 (25-03-2019)

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Nikaïa Smith, Nicolas Pietrancosta, Sophia Davidson, Jacques Dutrieux, Lise Chauveau, et al.. Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement. Nature Communications, 2017, 8, pp.14253. ⟨10.1038/ncomms14253⟩. ⟨hal-02075366⟩
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