A Window of Opportunity to Control the Bacterial Pathogen Pseudomonas aeruginosa Combining Antibiotics and Phages - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2014

A Window of Opportunity to Control the Bacterial Pathogen Pseudomonas aeruginosa Combining Antibiotics and Phages

Résumé

The evolution of antibiotic resistance in bacteria is a global concern and the use of bacteriophages alone or in combined therapies is attracting increasing attention as an alternative. Evolutionary theory predicts that the probability of bacterial resistance to both phages and antibiotics will be lower than to either separately, due for example to fitness costs or to trade-offs between phage resistance mechanisms and bacterial growth. In this study, we assess the population impacts of either individual or combined treatments of a bacteriophage and streptomycin on the nosocomial pathogen Pseudomonas aeruginosa. We show that combining phage and antibiotics substantially increases bacterial control compared to either separately, and that there is a specific time delay in antibiotic introduction independent of antibiotic dose, that minimizes both bacterial density and resistance to either antibiotics or phage. These results have implications for optimal combined therapeutic approaches.
Fichier principal
Vignette du fichier
2014_Torres Barcelo_Plos One_1.PDF (470.75 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-02015241 , version 1 (28-05-2020)

Licence

Paternité

Identifiants

Citer

Clara Torres-Barceló, Flor Arias-Sánchez, Marie Vasse, Johan Ramsayer, Oliver Kaltz, et al.. A Window of Opportunity to Control the Bacterial Pathogen Pseudomonas aeruginosa Combining Antibiotics and Phages. PLoS ONE, 2014, 9 (9), pp.e106628. ⟨10.1371/journal.pone.0106628⟩. ⟨hal-02015241⟩
85 Consultations
57 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More