Metal‐Free Decarboxylative Allylation of Oxime Esters under Light Irradiation - Université de Montpellier
Article Dans Une Revue Chemistry - A European Journal Année : 2024

Metal‐Free Decarboxylative Allylation of Oxime Esters under Light Irradiation

Résumé

Abstract Allylation reactions, often used as a key step for constructing complex molecules and drug candidates, typically rely on transition‐metal (TM) catalysts. Even though TM‐free radical allylations have been developed using allyl‐stannanes, ‐sulfides, ‐silanes or ‐sulfones, much less procedures have been reported using simple and commercially available allyl halides, that are used for the preparation of the before‐mentioned allyl derivatives. Here, we present a straightforward photocatalytic protocol for the decarboxylative allylation of oxime esters using allyl bromide derivatives under metal‐free and mild conditions. This methodology yields a diverse variety of functionalized molecules including several pharmaceutically relevant molecules.

Domaines

Chimie

Dates et versions

hal-04686773 , version 1 (04-09-2024)

Identifiants

Citer

Lilian Geniller, Hiba Ben Kraim, Eric Clot, Marc Taillefer, Florian Jaroschik, et al.. Metal‐Free Decarboxylative Allylation of Oxime Esters under Light Irradiation. Chemistry - A European Journal, 2024, 30 (43), pp.e202401494. ⟨10.1002/chem.202401494⟩. ⟨hal-04686773⟩
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