Cation-independent mannose 6-phosphate receptor: From roles and functions to targeted therapies - Université de Montpellier
Article Dans Une Revue Journal of Controlled Release Année : 2024

Cation-independent mannose 6-phosphate receptor: From roles and functions to targeted therapies

Khaled El Cheikh
Ilaria Basile
  • Fonction : Auteur
Morgane Daurat
Elodie Morère
  • Fonction : Auteur
Marcel Garcia
  • Fonction : Auteur
Marie Maynadier
  • Fonction : Auteur

Résumé

The cation-independent mannose 6-phosphate receptor (CI-M6PR) is a ubiquitous transmembrane receptor whose main intracellular role is to direct enzymes carrying mannose 6-phosphate moieties to lysosomal compartments. Recently, the small membrane-bound portion of this receptor has appeared to be implicated in numerous pathophysiological processes. This review presents an overview of the main ligand partners and the roles of CI-M6PR in lysosomal storage diseases, neurology, immunology and cancer fields. Moreover, this membrane receptor has already been noted for its strong potential in therapeutic applications thanks to its cellular internalization activity and its ability to address pathogenic factors to lysosomes for degradation. A number of therapeutic delivery approaches using CI-M6PR, in particular with enzymes, antibodies or nanoparticles, are currently being proposed.

Domaines

Cancer Immunologie
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Dates et versions

hal-04549218 , version 1 (17-04-2024)

Identifiants

Citer

Corentin Gauthier, Khaled El Cheikh, Ilaria Basile, Morgane Daurat, Elodie Morère, et al.. Cation-independent mannose 6-phosphate receptor: From roles and functions to targeted therapies. Journal of Controlled Release, 2024, 365, pp.759-772. ⟨10.1016/j.jconrel.2023.12.014⟩. ⟨hal-04549218⟩
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