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Article Dans Une Revue Pharmaceutics Année : 2023

Antioxidant Efficacy and “In Vivo” Safety of a Bentonite/Vitamin C Hybrid

Dayaris Hernández
Anaela Montalvo
  • Fonction : Auteur
Irela Pérez
  • Fonction : Auteur
Rita Sánchez-Espejo
Pilar Cerezo
  • Fonction : Auteur
César Viseras
Serena Riela
  • Fonction : Auteur
Giuseppe Cinà
  • Fonction : Auteur


L-ascorbic acid (LAA), commonly known as vitamin C, is an excellent and recognized antioxidant molecule used in pharmaceutical and cosmetic formulations. Several strategies have been developed in order to preserve its chemical stability, connected with its antioxidant power, but there is little research regarding the employment of natural clays as LAA host. A safe bentonite (Bent)—which was verified by in vivo ophthalmic irritability and acute dermal toxicity assays—was used as carrier of LAA. The supramolecular complex between LAA and clay may constitute an excellent alternative, since the molecule integrity does not seem to be affected, at least from the point of view of its antioxidant capacity. The Bent/LAA hybrid was prepared and characterized through ultraviolet (UV) spectroscopy, X-ray diffraction (XRD), infrared (IR) spectroscopy, thermogravimetric analysis (TG/DTG) and zeta potential measurements. Photostability and antioxidant capacity tests were also performed. The LAA incorporation into Bent clay was demonstrated, as well as the drug stability due to the Bent photoprotective effect onto the LAA molecule. Moreover, the antioxidant capacity of the drug in the Bent/LAA composite was confirmed.


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hal-04107681 , version 1 (13-11-2023)



Dayaris Hernández, Anaela Montalvo, Irela Pérez, Clarence Charnay, Rita Sánchez-Espejo, et al.. Antioxidant Efficacy and “In Vivo” Safety of a Bentonite/Vitamin C Hybrid. Pharmaceutics, 2023, 15 (4), pp.1171. ⟨10.3390/pharmaceutics15041171⟩. ⟨hal-04107681⟩
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