d -Mannose-appended 5,15-diazaporphyrin for photodynamic therapy - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Organic & Biomolecular Chemistry Année : 2022

d -Mannose-appended 5,15-diazaporphyrin for photodynamic therapy


5,15-Diazaporphyrin appended with D -mannose moieties was prepared through Suzuki–Miyaura crosscoupling reaction and SN 2 alkylation. The resultant diazaporphyrin was hydrophilic enough to exhibit sufficient solubility in aqueous media. Because of the photosensitizing ability of diazaporphyrins, the in vitro activity of the D -mannose-appended diazaporphyrin in photodynamic therapy (PDT) was investigated. The specific internalization of the functionalized diazaporphyrin into human breast adeno-carcinoma (MDA-MB-231) cells through mannose receptors was confirmed by confocal microscopy imaging. We also demonstrated the strong PDT activity of the functionalized diazaporphyrin at a nanomolar level with short light irradiation time.


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hal-03772642 , version 1 (08-09-2022)


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Lamiaa Ali, Kazuya Miyagawa, Norihito Fukui, Mélanie Onofre, Khaled El Cheikh, et al.. d -Mannose-appended 5,15-diazaporphyrin for photodynamic therapy. Organic & Biomolecular Chemistry, 2022, 20, in press. ⟨10.1039/d2ob01410f⟩. ⟨hal-03772642⟩
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