Cumulative Occupational Exposures and Lung-Function Decline in Two Large General-Population Cohorts
Theodore Lytras
(1, 2)
,
Anna Beckmeyer-Borowko
(3, 4)
,
Manolis Kogevinas
(1, 2, 5, 6)
,
Hans Kromhout
(7)
,
Anne-Elie Carsin
(1, 2, 5)
,
Josep Maria Antó
(1, 2, 5, 6)
,
Hayat Bentouhami
(8)
,
Joost Weyler
(8)
,
Joachim Heinrich
(9, 10)
,
Dennis Nowak
(9, 10)
,
Isabel Urrutia
(11)
,
Jesús Martínez-Moratalla
(12, 13)
,
José Antonio Gullón
,
Antonio Pereira Vega
(14)
,
Chantal Raherison Semjen
(15)
,
Isabelle Pin
(16, 17)
,
Pascal Demoly
(18, 19, 20)
,
Bénédicte Leynaert
(21)
,
Simona Villani
(22)
,
Thorarinn Gislason
(23, 24)
,
Øistein Svanes
(25)
,
Mathias Holm
(26)
,
Bertil Forsberg
(27)
,
Dan Norbäck
(28)
,
Amar Mehta
(29)
,
Dirk Keidel
(3, 4)
,
David Vernez
(30)
,
Geza Benke
(31)
,
Rain Jõgi
(32)
,
Kjell Torén
(33)
,
Torben Sigsgaard
(34)
,
Vivi Schlünssen
(34)
,
Mario Olivieri
(35)
,
Paul Blanc
(36)
,
John Watkins
(37)
,
Roberto Bono
(38)
,
Giulia Squillacioti
(38)
,
A. Sonia Buist
(39)
,
Roel Vermeulen
(7)
,
Deborah Jarvis
(40)
,
Nicole Probst-Hensch
(3, 4)
,
Jan-Paul Zock
(1, 2, 5)
1
ISGlobal -
Instituto de Salud Global - Institute For Global Health [Barcelona]
2 UPF - Universitat Pompeu Fabra [Barcelona]
3 Swiss Tropical and Public Health Institute [Basel]
4 Unibas - Université de Bâle = University of Basel = Basel Universität
5 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
6 IMIM-Hospital del Mar
7 Universiteit Utrecht / Utrecht University [Utrecht]
8 UA - University of Antwerp
9 Klinikum der Universitat Munchen
10 German Center for Lung Research
11 Galdakao Hospital
12 Complejo Hospitalario Universitario de Albacete
13 UCLM - Universidad de Castilla-La Mancha = University of Castilla-La Mancha
14 Hospital Universitario Juan Ramón Jiménez [Huelva]
15 EPICENE - Cancer environnement
16 Département de médecine aiguë spécialisée
17 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
18 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
19 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
20 IDESP - Institut Desbrest de santé publique
21 PHERE (UMR_S_1152 / U1152) - Physiopathologie et Epidémiologie des Maladies Respiratoires
22 UNIPV - Università degli Studi di Pavia [Italia] = University of Pavia [Italy] = Université de Pavie [Italie]
23 Landspitali National University Hospital of Iceland
24 University of Iceland [Reykjavik]
25 UiB - University of Bergen
26 Sahlgrenska University Hospital [Gothenburg]
27 Umeå University = Umeå Universitet
28 Uppsala University
29 UCPH - University of Copenhagen = Københavns Universitet
30 UNIL - Université de Lausanne = University of Lausanne
31 Monash University [Melbourne]
32 Tartu University Hospital [Tartu, Estonia]
33 Sahlgrenska Academy at University of Gothenburg [Göteborg]
34 Aarhus University [Aarhus]
35 UNIVR - Università degli studi di Verona = University of Verona
36 UC San Francisco - University of California [San Francisco]
37 Cardiff University
38 UNITO - Università degli studi di Torino = University of Turin
39 OHSU - Oregon Health and Science University [Portland]
40 Imperial College London
2 UPF - Universitat Pompeu Fabra [Barcelona]
3 Swiss Tropical and Public Health Institute [Basel]
4 Unibas - Université de Bâle = University of Basel = Basel Universität
5 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
6 IMIM-Hospital del Mar
7 Universiteit Utrecht / Utrecht University [Utrecht]
8 UA - University of Antwerp
9 Klinikum der Universitat Munchen
10 German Center for Lung Research
11 Galdakao Hospital
12 Complejo Hospitalario Universitario de Albacete
13 UCLM - Universidad de Castilla-La Mancha = University of Castilla-La Mancha
14 Hospital Universitario Juan Ramón Jiménez [Huelva]
15 EPICENE - Cancer environnement
16 Département de médecine aiguë spécialisée
17 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
18 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
19 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
20 IDESP - Institut Desbrest de santé publique
21 PHERE (UMR_S_1152 / U1152) - Physiopathologie et Epidémiologie des Maladies Respiratoires
22 UNIPV - Università degli Studi di Pavia [Italia] = University of Pavia [Italy] = Université de Pavie [Italie]
23 Landspitali National University Hospital of Iceland
24 University of Iceland [Reykjavik]
25 UiB - University of Bergen
26 Sahlgrenska University Hospital [Gothenburg]
27 Umeå University = Umeå Universitet
28 Uppsala University
29 UCPH - University of Copenhagen = Københavns Universitet
30 UNIL - Université de Lausanne = University of Lausanne
31 Monash University [Melbourne]
32 Tartu University Hospital [Tartu, Estonia]
33 Sahlgrenska Academy at University of Gothenburg [Göteborg]
34 Aarhus University [Aarhus]
35 UNIVR - Università degli studi di Verona = University of Verona
36 UC San Francisco - University of California [San Francisco]
37 Cardiff University
38 UNITO - Università degli studi di Torino = University of Turin
39 OHSU - Oregon Health and Science University [Portland]
40 Imperial College London
Theodore Lytras
- Fonction : Auteur
- PersonId : 785179
- ORCID : 0000-0002-4146-4122
Manolis Kogevinas
- Fonction : Auteur
- PersonId : 762958
- ORCID : 0000-0002-9605-0461
Josep Maria Antó
- Fonction : Auteur
José Antonio Gullón
- Fonction : Auteur
Isabelle Pin
- Fonction : Auteur
- PersonId : 756749
- ORCID : 0000-0002-7529-6999
Pascal Demoly
- Fonction : Auteur
- PersonId : 754222
- IdHAL : pascal-demoly
- ORCID : 0000-0001-7827-7964
- IdRef : 03442959X
Bénédicte Leynaert
- Fonction : Auteur
- PersonId : 1064367
- IdHAL : benedicte-leynaert
- ORCID : 0000-0001-5045-2492
Kjell Torén
- Fonction : Auteur
- PersonId : 759883
- ORCID : 0000-0001-8509-7603
Torben Sigsgaard
- Fonction : Auteur
- PersonId : 765182
- ORCID : 0000-0002-2043-7571
- IdRef : 153387408
Résumé
Rationale: Few longitudinal studies have assessed the relationship between occupational exposures and lung-function decline in the general population with a sufficiently long follow-up.Objectives: To examine the potential association in two large cohorts: the ECRHS (European Community Respiratory Health Survey) and the SAPALDIA (Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults).Methods: General-population samples of individuals aged 18 to 62 were randomly selected in 1991-1993 and followed up approximately 10 and 20 years later. Spirometry (without bronchodilation) was performed at each visit. Coded complete job histories during follow-up visits were linked to a job-exposure matrix, generating cumulative exposure estimates for 12 occupational exposures. Forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were jointly modeled in linear mixed-effects models, fitted in a Bayesian framework, taking into account age and smoking.Results: A total of 40,024 lung-function measurements from 17,833 study participants were analyzed. We found accelerated declines in FEV1 and the FEV1/FVC ratio for exposure to biological dust, mineral dust, and metals (FEV1 = -15.1 ml, -14.4 ml, and -18.7 ml, respectively; and FEV1/FVC ratio = -0.52%, -0.43%, and -0.36%, respectively; per 25 intensity-years of exposure). These declines were comparable in magnitude with those associated with long-term smoking. No effect modification by sex or smoking status was identified. Findings were similar between the ECRHS and the SAPALDIA cohorts.Conclusions: Our results greatly strengthen the evidence base implicating occupation, independent of smoking, as a risk factor for lung-function decline. This highlights the need to prevent or control these exposures in the workplace.
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