White matter disconnectivity fingerprints causally linked to dissociated forms of alexia - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Communications Biology Année : 2021

White matter disconnectivity fingerprints causally linked to dissociated forms of alexia

Résumé

For over 150 years, the study of patients with acquired alexia has fueled research aimed at disentangling the neural system critical for reading. An unreached goal, however, relates to the determination of the fiber pathways that root the different visual and linguistic processes needed for accurate word reading. In a unique series of neurosurgical patients with a tumor close to the visual word form area, we combine direct electrostimulation and population-based streamline tractography to map the disconnectivity fingerprints characterizing dissociated forms of alexia. Comprehensive analyses of disconnectivity matrices establish similarities and dissimilarities in the disconnection patterns associated with pure, phonological and lexical-semantic alexia. While disconnections of the inferior longitudinal and posterior arcuate fasciculi are common to all alexia subtypes, disconnections of the long arcuate and vertical occipital fasciculi are specific to phonological and pure alexia, respectively. These findings provide a strong anatomical background for cognitive and neurocomputational models of reading.
Fichier principal
Vignette du fichier
s42003-021-02943-z.pdf (2.64 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03634907 , version 1 (08-04-2022)

Licence

Identifiants

Citer

Sam Ng, Sylvie Moritz-Gasser, Anne-Laure Lemaitre, Hugues Duffau, Guillaume Herbet. White matter disconnectivity fingerprints causally linked to dissociated forms of alexia. Communications Biology, 2021, 4 (1), pp.1413. ⟨10.1038/s42003-021-02943-z⟩. ⟨hal-03634907⟩
33 Consultations
55 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More