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Article Dans Une Revue Free Radical Research Année : 2015

Current development in non-enzymatic lipid peroxidation products, isoprostanoids and isofuranoids, in novel biological samples

Résumé

Isoprostanoids and isofuranoids are lipid mediators that can be formed from omega-3 and omega-6 polyunsaturated fatty acids (PUFAs). F2-isoprostanes formed from arachidonic acid, especially 15-F2t-isoprostane, are commonly measured in biological tissues for decades as the biomarker for oxidative stress and diseases. Recently, other forms of isoprostanoids derived from adrenic, eicosapentaenoic, and docosahexaenoic acids namely F2-dihomo-isoprostanes, F3-isoprostanes, and F4-neuroprostanes respectively, and isofuranoids including isofurans, dihomo-isofurans, and neurofurans are reported as oxidative damage markers for different metabolisms. The most widely used samples in measuring lipid peroxidation products include but not limited to the blood and urine; other biological fluids, specialized tissues, and cells can also be determined. In this review, measurement of isoprostanoids and isofuranoids in novel biological samples by gas chromatography (GC)-mass spectrometry (MS), GC-MS/MS, liquid chromatography (LC)-MS, and LC-MS/MS will be discussed.

Domaines

Chimie
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Dates et versions

hal-03624286 , version 1 (30-03-2022)

Identifiants

Citer

K. Leung, Jean-Marie Galano, Thierry Durand, J. C.-Y. Lee. Current development in non-enzymatic lipid peroxidation products, isoprostanoids and isofuranoids, in novel biological samples. Free Radical Research, 2015, 49 (7), pp.816-826. ⟨10.3109/10715762.2014.960867⟩. ⟨hal-03624286⟩
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