Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors: a patent evaluation of US20160011199A1 - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Expert Opinion on Therapeutic Patents Année : 2016

Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors: a patent evaluation of US20160011199A1

Résumé

The present patent discloses the identification of small-molecule fluorescent probes constituted by pteroic acid moiety connected to near-infrared (NIR) dye via amino acids. These folate receptor (FR) targeted conjugates were shown to have high affinity for tumors that overexpress FRs. A selected compound from this new class, pteroyl-L-tyrosine-S0456 (OTL-0038), displays high affinity and specificity for FRs and was shown (i) to accumulate in vivo in tumor cells expressing FRs, and (ii) to be non-toxic in mice at clinical dose x 1000. This compound holds considerable promise for the location and detection of tumoral cells in the context of fluorescence guided surgery.

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Chimie
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Dates et versions

hal-03621603 , version 1 (28-03-2022)

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Citer

Jean-Yves Winum. Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors: a patent evaluation of US20160011199A1. Expert Opinion on Therapeutic Patents, 2016, 26 (11), pp.1223-1226. ⟨10.1080/13543776.2016.1241238⟩. ⟨hal-03621603⟩
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