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Article Dans Une Revue ACS Medicinal Chemistry Letters Année : 2015

Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series

Résumé

A general approach for the synthesis of carbonic anhydrases glycoinhibitors belonging to an aminoxysulfonamide series is presented using a Ferrier sulfonamidoglycosylation reaction on glycals. All the compounds showed good in vitro inhibitory activity against four human carbonic anhydrase isoforms, with selectivity against the cytosolic (hCA II) vs the tumor associated (hCA IX and XII) enzymes.

Dates et versions

hal-03621576 , version 1 (28-03-2022)

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Citer

Joanna Ombouma, Daniella Vullo, Pascal Dumy, Claudiu Supuran, Jean-Yves Winum. Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series. ACS Medicinal Chemistry Letters, 2015, 6 (7), pp.819-821. ⟨10.1021/acsmedchemlett.5b00175⟩. ⟨hal-03621576⟩
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