Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators - Université de Montpellier
Article Dans Une Revue Bioorganic and Medicinal Chemistry Année : 2014

Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators

Résumé

Mono- and di-halogenated histamines, l-histidine methyl ester derivatives and carnosine derivatives incorporating chlorine, bromine and iodine were prepared and investigated as activators of five carbonic anhydrase (CA, EC 4.2.1.1) isoforms, the cytosolic hCA I, II and VII, and the transmembrane hCA XII and XIV. All of them were activated in a diverse manner by the investigated compounds, with a distinct activation profile.

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Chimie
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Dates et versions

hal-03619378 , version 1 (25-03-2022)

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Citer

Mohamed-Chiheb Saada, Daniela Vullo, Jean-Louis Montero, Andrea Scozzafava, Claudiu Supuran, et al.. Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators. Bioorganic and Medicinal Chemistry, 2014, 22 (17), pp.4752-4758. ⟨10.1016/j.bmc.2014.07.005⟩. ⟨hal-03619378⟩
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