MgI 2 ‐chemoselective cleavage for removal of amino acid protecting groups: A fresh vision for peptide synthesis - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Biopolymers Année : 2017

MgI 2 ‐chemoselective cleavage for removal of amino acid protecting groups: A fresh vision for peptide synthesis

Résumé

In the field of peptide synthesis, the key to a successful access to synthetic targets lies on a pertinent combination of protecting groups. Their choice is directed by their selective removal conditions. We present here the behavior of some of the most used protecting groups in peptide chemistry under experimental cleavage conditions, combining MgI2 with MW irradiation, using 2-Me-THF as a green solvent. In these experimental conditions, the benzyloxycarbonyl protecting group as well as the Merrifield resin can be re-considered in peptide chemistry.

Domaines

Chimie
Fichier non déposé

Dates et versions

hal-03572182 , version 1 (14-02-2022)

Identifiants

Citer

Mathéo Berthet, Jean Martinez, Isabelle Parrot. MgI 2 ‐chemoselective cleavage for removal of amino acid protecting groups: A fresh vision for peptide synthesis. Biopolymers, 2017, 108 (2), pp.e22908. ⟨10.1002/bip.22908⟩. ⟨hal-03572182⟩
4 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More