Molecular oxygen loading in candidate theranostic droplets stabilized with biocompatible fluorinated surfactants: Particle size effect and application to in situ 19F MRI mapping of oxygen partial pressure - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Journal of Magnetic Resonance Année : 2018

Molecular oxygen loading in candidate theranostic droplets stabilized with biocompatible fluorinated surfactants: Particle size effect and application to in situ 19F MRI mapping of oxygen partial pressure

Résumé

Perfluorocarbon nano- and micron-sized emulsions are a new field of investigation in cancer treatment due to their ability to be used as imaging contrast agents, or as delivery vectors for pharmaceuticals. They also demonstrated capability to enhance the efficiency of high intensity focused ultrasound thermo-therapy. In the context of new biomedical applications we investigated perfluorooctyl bromide (PFOB) theranostic droplets using 19F NMR. Each droplet contains biocompatible fluorinated surfactants composed of a polar Tris(hydroxymethyl)aminomethane head unit and hydrophobic perfluorinated tail (abbreviated as F-TAC). The influence of the droplet size on the oxygen loading capacity was determined from longitudinal relaxation (T1) data of 19F NMR signal.
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Dates et versions

hal-03559766 , version 1 (07-02-2022)

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Orane Lorton, Jean-Noël Hyacinthe, Stéphane Desgranges, Laura Gui, Antoine Klauser, et al.. Molecular oxygen loading in candidate theranostic droplets stabilized with biocompatible fluorinated surfactants: Particle size effect and application to in situ 19F MRI mapping of oxygen partial pressure. Journal of Magnetic Resonance, 2018, 295, pp.27-37. ⟨10.1016/j.jmr.2018.07.019⟩. ⟨hal-03559766⟩
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