Synthesis of 3′-halo-5′-norcarbocyclic nucleoside phosphonates as potent anti-HIV agents - Université de Montpellier
Article Dans Une Revue European Journal of Medicinal Chemistry Année : 2018

Synthesis of 3′-halo-5′-norcarbocyclic nucleoside phosphonates as potent anti-HIV agents

Résumé

The synthesis and the antiviral evaluation of 3'-halo (iodo and fluoro) 5'-norcarbocyclic nucleoside phosphonates is described. No antiviral activity was observed against Zika virus, Dengue virus 2, HSV-1, HSV-2 and Chikungunya virus. In contrast, some of the synthesized compounds are potent inhibitors of the replication of HIV-1, comparatively to (R)-PMPA, with no concomitant cytotoxicity.

Domaines

Chimie
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Dates et versions

hal-03556766 , version 1 (04-02-2022)

Identifiants

Citer

Nadège Hamon, Malika Kaci, Jean-Pierre Uttaro, Christian Périgaud, Christophe Mathé. Synthesis of 3′-halo-5′-norcarbocyclic nucleoside phosphonates as potent anti-HIV agents. European Journal of Medicinal Chemistry, 2018, 150, pp.642-654. ⟨10.1016/j.ejmech.2018.03.038⟩. ⟨hal-03556766⟩
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