The contribution of chiral sulfoxides as versatile auxiliaries in the field of organic chemistry has shown a prevalent interest in the asymmetric synthesis of natural products during the last 45 years. In this short review, we report the recent applications of these chiral auxiliaries to the synthesis of natural and biological active products highlighted from 2010 to 2019. We hope to allow the reader to have an overview of the potential of sulfoxide chemistry in the field of enantio­selective synthesis. 1 Introduction 2 Diastereoselective Additions to Ketones 2.1 Reduction of β-Keto Sulfoxides 2.2 Reduction of β-Keto Sulfoxides Followed by Bromohydrin Forma tion 3 Synthesis of an α-Amino α′-Sulfinyl Ketone Followed by Diastere oselective Reduction of the β-Keto Sulfoxide 4 Diastereoselective Addition of Carbanionic Chiral Sulfoxides 4.1 Addition to an Aldehyde 4.1.1 Aldol Reactions 4.1.2 Reformatsky-Type Reactions 4.2 Additions to Chiral Sulfinimines 5 Diastereoselective Cyclization Reactions Directed by a Chiral Sulf oxide 5.1 1,4-Radical Additions 5.2 Intramolecular Conjugate Additions 5.3 Nazarov Cyclizations 5.4 Diels–Alder Reactions 6 Atropodiastereoselective Synthesis 7 Conclusion