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Long-term follow-up of patients with mantle cell lymphoma (MCL) treated with the selective Bruton’s tyrosine kinase inhibitor tirabrutinib (GS/ONO-4059)

Simon Rule 1 Guillaume Cartron 2 Christopher Fegan 3 Franck Morschhauser 4, 5 Lingling Han 6 Siddhartha Mitra 6 Gilles Salles 7 Martin Dyer 8 
1 Plymouth University
2 LPHI - LPHI - Laboratory of Pathogen Host Interactions
3 School of Medicine [Cardiff]
4 Recherche translationelle relations hôte-pathogènes
5 Service d'Hématologie Cellulaire [Lille]
6 Gilead Sciences
7 HCL - Hospices Civils de Lyon
8 Ernest and Helen Scott Haematological Research Institute
Abstract : Recent therapeutic advances for mantle cell lymphoma (MCL) include inhibitors of Bruton’s tyrosine kinase (BTK), a critical component in the B-cell receptor signaling pathway [1, 2]. Remarkably, approximately two thirds of patients with relapsed/refractory (R/R) MCL treated with ibrutinib, the first-in-class BTK inhibitor, achieve a durable response [3–5]. However, ibrutinib treatment also commonly produces off-target adverse events (AEs) such as bleeding, atrial fibrillation, diarrhea, and infection.
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https://hal.umontpellier.fr/hal-03383683
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Soumis le : lundi 18 octobre 2021 - 16:21:48
Dernière modification le : jeudi 19 mai 2022 - 15:56:02

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HCL | CNRS | UNIV-MONTPELLIER | UNIV-LILLE | LPHI

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Simon Rule, Guillaume Cartron, Christopher Fegan, Franck Morschhauser, Lingling Han, et al.. Long-term follow-up of patients with mantle cell lymphoma (MCL) treated with the selective Bruton’s tyrosine kinase inhibitor tirabrutinib (GS/ONO-4059). Leukemia, Nature Publishing Group: Open Access Hybrid Model Option B, 2020, 34 (5), pp.1458-1461. ⟨10.1038/s41375-019-0658-7⟩. ⟨hal-03383683⟩

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