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Article Dans Une Revue Antioxidants Année : 2021

Lipid Peroxidation Assessment in Preclinical Alzheimer Disease Diagnosis

Carmen Peña-Bautista
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Lourdes Álvarez-Sánchez
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Inés Ferrer
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Marina López-Nogueroles
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Miguel Baquero
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Consuelo Cháfer-Pericás


Alzheimer disease (AD) is an increasingly common neurodegenerative disease, especially in countries with aging populations. Its diagnosis is complex and is usually carried out in advanced stages of the disease. In addition, lipids and oxidative stress have been related to AD since the earliest stages. A diagnosis in the initial or preclinical stages of the disease could help in a more effective action of the treatments. Isoprostanoid biomarkers were determined in plasma samples from preclinical AD participants (n = 12) and healthy controls (n = 31) by chromatography and mass spectrometry (UPLC-MS/MS). Participants were accurately classified according to cerebrospinal fluid (CSF) biomarkers and neuropsychological examination. Isoprostanoid levels did not show differences between groups. However, some of them correlated with CSF biomarkers (t-tau, p-tau) and with cognitive decline. In addition, a panel including 10 biomarkers showed an area under curve (AUC) of 0.96 (0.903–1) and a validation AUC of 0.90 in preclinical AD prediction. Plasma isoprostanoids could be useful biomarkers in preclinical diagnosis for AD. However, these results would require a further validation with an external cohort.
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Dates et versions

hal-03378780 , version 1 (14-10-2021)





Carmen Peña-Bautista, Lourdes Álvarez-Sánchez, Inés Ferrer, Marina López-Nogueroles, Antonio José Cañada-Martínez, et al.. Lipid Peroxidation Assessment in Preclinical Alzheimer Disease Diagnosis. Antioxidants , 2021, 10 (7), pp.1043. ⟨10.3390/antiox10071043⟩. ⟨hal-03378780⟩
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