Lipid Peroxidation Assessment in Preclinical Alzheimer Disease Diagnosis - Université de Montpellier
Article Dans Une Revue Antioxidants Année : 2021

Lipid Peroxidation Assessment in Preclinical Alzheimer Disease Diagnosis

Résumé

Alzheimer disease (AD) is an increasingly common neurodegenerative disease, especially in countries with aging populations. Its diagnosis is complex and is usually carried out in advanced stages of the disease. In addition, lipids and oxidative stress have been related to AD since the earliest stages. A diagnosis in the initial or preclinical stages of the disease could help in a more effective action of the treatments. Isoprostanoid biomarkers were determined in plasma samples from preclinical AD participants (n = 12) and healthy controls (n = 31) by chromatography and mass spectrometry (UPLC-MS/MS). Participants were accurately classified according to cerebrospinal fluid (CSF) biomarkers and neuropsychological examination. Isoprostanoid levels did not show differences between groups. However, some of them correlated with CSF biomarkers (t-tau, p-tau) and with cognitive decline. In addition, a panel including 10 biomarkers showed an area under curve (AUC) of 0.96 (0.903–1) and a validation AUC of 0.90 in preclinical AD prediction. Plasma isoprostanoids could be useful biomarkers in preclinical diagnosis for AD. However, these results would require a further validation with an external cohort.
Fichier principal
Vignette du fichier
Pena-Bautista et al antioxidants- 2021 10 01043.pdf (1.72 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03378780 , version 1 (14-10-2021)

Licence

Identifiants

Citer

Carmen Peña-Bautista, Lourdes Álvarez-Sánchez, Inés Ferrer, Marina López-Nogueroles, Antonio José Cañada-Martínez, et al.. Lipid Peroxidation Assessment in Preclinical Alzheimer Disease Diagnosis. Antioxidants , 2021, 10 (7), pp.1043. ⟨10.3390/antiox10071043⟩. ⟨hal-03378780⟩
31 Consultations
46 Téléchargements

Altmetric

Partager

More