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Article Dans Une Revue Current Opinion in Biotechnology Année : 2000

Translocating peptides and proteins and their use for gene delivery

Résumé

A dramatic surge in the development of peptides for gene delivery in vitro and in vivo has been witnessed in the past decade. A better understanding of the structural and mechanistic properties of peptides has been an important step for the rational design of optimal peptide-based gene delivery systems. Research has focused on the design of short synthetic peptides that overcome both extracellular and intracellular limitations of other gene delivery systems by binding reversibly and condensing DNA, specifically targeting cells and/or tissues, rapidly releasing plasmids into the cytoplasm and mediating efficient nuclear translocation.
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Dates et versions

hal-03130072 , version 1 (03-02-2021)

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May Morris, Laurent Chaloin, Frederic Heitz, Gilles Divita. Translocating peptides and proteins and their use for gene delivery. Current Opinion in Biotechnology, 2000, 11 (5), pp.461-466. ⟨10.1016/s0958-1669(00)00128-2⟩. ⟨hal-03130072⟩
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