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Article Dans Une Revue Molecular Biology and Evolution Année : 2016

R2d2 Drives Selfish Sweeps in the House Mouse

1 UNC Lineberger - Lineberger Comprehensive Cancer Center
2 Carolina Center for Genome Sciences
3 UMR ISEM - Institut des Sciences de l'Evolution de Montpellier
4 JAX - The Jackson Laboratory [Bar Harbor]
5 Island Conservation
6 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
7 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
8 Elon University [NC, USA]
9 UNC - University of North Carolina [Chapel Hill]
10 IZW - Leibniz Institute for Zoo and Wildlife Research
11 NIEHS-NIH - National Institute of Environmental Health Sciences [Durham]
12 CESAM - Centre for Environmental and Marine Studies [Aveiro]
13 ULISBOA - Universidade de Lisboa = University of Lisbon
14 UC Riverside - University of California [Riverside]
15 Department of Biology [Patras]
16 CONICET - Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires]
17 Universidad Nacional de Misiones
18 UZH - Universität Zürich [Zürich] = University of Zurich
19 OMU - Ondokuz Mayis University
20 NIAAA - National Institute on Alcohol Abuse and Alcoholism
21 FEM - Fondazione Edmund Mach - Edmund Mach Foundation [Italie]
22 Department of Computer Science [Chapel Hill]
23 UB - Universitat de Barcelona
24 National Institute of Diabetes and Digestive and Kidney Diseases [Bethesda]
25 Department of Ecology and Evolutionary Biology [Ithaca]
26 Mahidol University [Bangkok]
27 Texas A&M University [College Station]
28 UAB - Universitat Autònoma de Barcelona
Yung-Hao Ching
  • Fonction : Auteur
Jeremy Herman
  • Fonction : Auteur
Karen Svenson

Résumé

A selective sweep is the result of strong positive selection driving newly occurring or standing genetic variants to fixation, and can dramatically alter the pattern and distribution of allelic diversity in a population. Population-level sequencing data have enabled discoveries of selective sweeps associated with genes involved in recent adaptations in many species. In contrast, much debate but little evidence addresses whether "selfish" genes are capable of fixation-thereby leaving signatures identical to classical selective sweeps-despite being neutral or deleterious to organismal fitness. We previously described R2d2, a large copy-number variant that causes nonrandom segregation of mouse Chromosome 2 in females due to meiotic drive. Here we show population-genetic data consistent with a selfish sweep driven by alleles of R2d2 with high copy number (R2d2(HC)) in natural populations. We replicate this finding in multiple closed breeding populations from six outbred backgrounds segregating for R2d2 alleles. We find that R2d2(HC) rapidly increases in frequency, and in most cases becomes fixed in significantly fewer generations than can be explained by genetic drift. R2d2(HC) is also associated with significantly reduced litter sizes in heterozygous mothers, making it a true selfish allele. Our data provide direct evidence of populations actively undergoing selfish sweeps, and demonstrate that meiotic drive can rapidly alter the genomic landscape in favor of mutations with neutral or even negative effects on overall Darwinian fitness. Further study will reveal the incidence of selfish sweeps, and will elucidate the relative contributions of selfish genes, adaptation and genetic drift to evolution.
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hal-03040525 , version 1 (16-06-2021)

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John Didion, Andrew Morgan, Liran Yadgary, Timothy Bell, Rachel Mcmullan, et al.. R2d2 Drives Selfish Sweeps in the House Mouse. Molecular Biology and Evolution, 2016, 33 (6), pp.1381-1395. ⟨10.1093/molbev/msw036⟩. ⟨hal-03040525⟩
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