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Article Dans Une Revue iScience Année : 2020

Transmissible Cancers in an Evolutionary Perspective

Résumé

Inter-individual transmission of cancer cells represents an intriguing and unexplored host-pathogen system, with significant ecological and evolutionary ramifications. The pathogen consists of clonal malignant cell lines that spread horizontally as allografts and/or xenografts. Although only nine transmissible cancer lineages in eight host species from both terrestrial and marine environments have been investigated, they exhibit evolutionary dynamics that may provide novel insights into tumor-host interactions particularly in the formation of metastases. Here we present an overview of known transmissible cancers, discuss the necessary and sufficient conditions for cancer transmission, and provide a comprehensive review on the evolutionary dynamics between transmissible cancers and their hosts.
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hal-03027917 , version 1 (27-11-2020)

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Antoine M Dujon, Robert Gatenby, Georgina Bramwell, Nick Macdonald, Erin Dohrmann, et al.. Transmissible Cancers in an Evolutionary Perspective. iScience, 2020, 23 (7), pp.101269. ⟨10.1016/j.isci.2020.101269⟩. ⟨hal-03027917⟩
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