Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

MicroRNAs in juvenile idiopathic arthritis: can we learn more about pathophysiological mechanisms?

Abstract : Juvenile idiopathic arthritis (JIA) is a heterogeneous and multifactorial group of chronic arthritis with an onset before the age of 16 years. The pathogenesis of this disease is poorly understood, which makes the distinction among subtypes unclear, delays diagnosis and optimal therapeutic management. MicroRNAs (miRNAs) are small non-coding RNAs that play a critical role in the regulation of immune responses. Their expression is tightly controlled to ensure cellular homeostasis and function of innate and adaptive immune cells. Abnormal expression of miRNAs has been associated with the development of many inflammatory and autoimmune diseases. In this review, we gather results published on miRNAs expression profiles in JIA patients with the aim to identify miRNAs that can be used as diagnostic biomarkers and provide information on disease activity and progression. We also focus on miRNAs deregulated in different forms of JIA to shed light on common pathways potentially involved in disease pathophysiology.
Liste complète des métadonnées
Contributeur : Odile Hennaut Connectez-vous pour contacter le contributeur
Soumis le : mercredi 25 novembre 2020 - 16:52:17
Dernière modification le : vendredi 9 septembre 2022 - 10:20:08
Archivage à long terme le : : vendredi 26 février 2021 - 19:42:19


Fichiers produits par l'(les) auteur(s)


Distributed under a Creative Commons Paternité - Pas d'utilisation commerciale - Partage selon les Conditions Initiales 4.0 International License




Nadege Nziza, Isabelle Duroux-Richard, Florence Apparailly. MicroRNAs in juvenile idiopathic arthritis: can we learn more about pathophysiological mechanisms?. Autoimmunity Reviews, Elsevier, 2019, 18 (8), pp.796-804. ⟨10.1016/j.autrev.2019.06.006⟩. ⟨hal-03024109⟩



Consultations de la notice


Téléchargements de fichiers