Understanding Host–Pathogen–Vector Interactions with Chronic Asymptomatic Malaria Infections - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Trends in Parasitology Année : 2021

Understanding Host–Pathogen–Vector Interactions with Chronic Asymptomatic Malaria Infections

Résumé

The last malaria parasite standing will display effective adaptations to selective forces. While substantial progress has been made in reducing malaria mortality, eradication will require elimination of all Plasmodium parasites, including those in asymptomatic infections. These typically chronic, low-density infections are difficult to detect, yet can persist for months. We argue that asymptomatic infection is the parasite’s best asset for survival but it can be exploited if studied as a new model for host–pathogen–vector interactions. Regular sampling from cohorts of asymptomatic individuals can provide a means to investigate continuous parasite development within its natural host. State-of-the-art techniques can now be applied to such infections. This approach may reveal key molecular drivers of chronic infections – a critical step for malaria eradication.
Fichier principal
Vignette du fichier
Opinion_TrendsInPara_Asympto_vAuteur.pdf (593.5 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-02981651 , version 1 (24-10-2022)

Identifiants

Citer

Prince B Nyarko, Antoine Claessens. Understanding Host–Pathogen–Vector Interactions with Chronic Asymptomatic Malaria Infections. Trends in Parasitology, 2021, 37 (3), pp.195-204. ⟨10.1016/j.pt.2020.09.017⟩. ⟨hal-02981651⟩
121 Consultations
93 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More