Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

The role of innate immunity in the protection conferred by a bacterial infection against cancer: study of an invertebrate model

Abstract : All multicellular organisms are exposed to a diversity of infectious agents and to the emergence and proliferation of malignant cells. The protection conferred by some infections against cancer has been recently linked to the production of acquired immunity efectors such as antibodies. However, the evolution of innate immunity as a mechanism to prevent cancer and how it is jeopardized by infections remain poorly investigated. Here, we explored this question by performing experimental infections in two genetically modifed invertebrate models (Drosophila melanogaster) that develop invasive or non-invasive neoplastic brain tumors. After quantifying tumor size and antimicrobial peptide gene expression, we found that Drosophila larvae infected with a naturally occurring bacterium had smaller tumors compared to controls and to fungus-infected larvae. This was associated with the upregulation of genes encoding two antimicrobial peptides—diptericin and drosomycin—that are known to be important mediators of tumor cell death. We further confrmed that tumor regression upon infection was associated with an increase in tumor cell death. Thus, our study suggests that infection could have a protective role through the production of antimicrobial peptides that increase tumor cell death.Finally, our study highlights the need to understand the role of innate immune efectors in the complex interactions between infections and cancer cell communities in order to develop innovative cancer treatment strategies.
Liste complète des métadonnées

Littérature citée [53 références]  Voir  Masquer  Télécharger

https://hal.umontpellier.fr/hal-02960118
Contributeur : Pascale Roussel <>
Soumis le : mercredi 7 octobre 2020 - 13:45:42
Dernière modification le : mardi 8 décembre 2020 - 03:33:50
Archivage à long terme le : : vendredi 8 janvier 2021 - 18:39:14

Fichier

41598_2020_Article_66813 (1).p...
Fichiers éditeurs autorisés sur une archive ouverte

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Citation

Camille Jacqueline, Jean-Philippe Parvy, Marie-Lou Rollin, Dominique Faugère, François Renaud, et al.. The role of innate immunity in the protection conferred by a bacterial infection against cancer: study of an invertebrate model. Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.10106. ⟨10.1038/s41598-020-66813-0⟩. ⟨hal-02960118⟩

Partager

Métriques

Consultations de la notice

76

Téléchargements de fichiers

50