The extraordinary impact of metal-based complexes on synthetic methods is still recognized nowadays, and attempts are currently undertaken to further extend the use of metal-assisted chemistry to environmentally friendly processes within the strongly invoked green chemistry paradigm. In recent years, mechanochemistry seems to provide attractive responses with processing methods having origins lost in the mists of time. Focusing on the panorama of organic synthesis, this Review highlights some recently developed metal-assisted mechanochemical reactions to introduce the reader into the fascinating, quite unexplored world of mechanochemistry.