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Article dans une revue

Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping

Abstract : Polycomb repressive complexes 1 and 2 have been historically described as transcriptional repressors, but recent reports suggest that PRC1 might also support activation, although the underlying mechanisms remain elusive. Here, we show that stage-specific PRC1 binding at a subset of active promoters and enhancers during Drosophila development coincides with the formation of three-dimensional (3D) loops, an increase in expression during development and repression in PRC1 mutants. Dissection of the dachshund locus indicates that PRC1-anchored loops are versatile architectural platforms that persist when surrounding genes are transcriptionally active and fine-tune their expression. The analysis of RING1B binding profiles and 3D contacts during neural differentiation in mice suggests that this role is conserved in mammals.
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https://hal.umontpellier.fr/hal-02896366
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Soumis le : vendredi 10 juillet 2020 - 14:43:45
Dernière modification le : vendredi 5 août 2022 - 10:32:49
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V. Loubiere, G. L. Papadopoulos, Q. Szabo, A. M. Martinez, Giacomo Cavalli. Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping. Science Advances , American Association for the Advancement of Science (AAAS), 2020, 6 (2), pp.eaax4001. ⟨10.1126/sciadv.aax4001⟩. ⟨hal-02896366⟩

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