Immunothérapie en urologie : principes et résultats - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Progrès en Urologie Année : 2019

[Immunotherapy in urology: Concept and results]

Immunothérapie en urologie : principes et résultats


Objective: The purpose of this article is to update current data on immunotherapy in uro-oncology. Material and methods: Synthesis of data from recent literature and data presented at national and international conferences on immunotherapy in urological cancers. Results: Current immunotherapies restore the anti-tumor immunity, by blocking immunity-negative feedback checkpoints. In metastatic renal cell carcinoma and bladder carcinoma, immunotherapy has first shown a significant survival benefit in second-line, and more recently in first-line for kidney cancer. Trials are currently ongoing in adjuvant and neoadjuvant settings. In prostate cancer, there is little data and immunotherapy seems to benefit a limited subgroup of patients. Conclusion: Immunotherapy is a key treatment in kidney and bladder cancer. In the future, the identification of predictive markers should allow us to better select patients responding to immunotherapy.
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Dates et versions

hal-02859851 , version 1 (08-06-2020)



G. Pignot, N. Houédé. Immunothérapie en urologie : principes et résultats. Progrès en Urologie, 2019, 29 (15), pp.922-928. ⟨10.1016/j.purol.2019.08.267⟩. ⟨hal-02859851⟩
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