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Article Dans Une Revue Synthesis: Journal of Synthetic Organic Chemistry Année : 2018

History of Chemical Routes towards Cyclic Non-Enzymatic Oxygenated Metabolites of Polyunsaturated Fatty Acids

Résumé

Enzymatically formed oxygenated metabolites of polyunsaturated fatty acids (PUFA) are of great interest for the scientific community being mediators and biomarkers in the physiological and pathological regulation of many key biological processes. More recently; metabolites of PUFA formed through a non-enzymatic free radical pathway have gained interest in diseases linked with oxidative stress. Thus, synthetic strategies leading to the total synthesis of such metabolites are an essential field of research, and this review will cover a structural presentation, will discuss their biological interests, and present total syntheses reported between 2008 and 2017.

Domaines

Chimie
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Dates et versions

hal-02613521 , version 1 (03-06-2021)

Identifiants

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Camille Oger, Claire Cuyamendous, Aurélien de La Torre, Mathieu Candy, Alexandre Guy, et al.. History of Chemical Routes towards Cyclic Non-Enzymatic Oxygenated Metabolites of Polyunsaturated Fatty Acids. Synthesis: Journal of Synthetic Organic Chemistry, 2018, 50 (17), pp.3257-3280. ⟨10.1055/s-0036-1589540⟩. ⟨hal-02613521⟩
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