History of Chemical Routes towards Cyclic Non-Enzymatic Oxygenated Metabolites of Polyunsaturated Fatty Acids

Enzymatically formed oxygenated metabolites of polyunsaturated fatty acids (PUFA) are of great interest for the scientific community being mediators and biomarkers in the physiological and pathological regulation of many key biological processes. More recently; metabolites of PUFA formed through a non-enzymatic free radical pathway have gained interest in diseases linked with oxidative stress. Thus, synthetic strategies leading to the total synthesis of such metabolites are an essential field of research, and this review will cover a structural presentation, will discuss their biological interests, and present total syntheses reported between 2008 and 2017.

Mots clés

total synthesis - lipids - isoprostanes

Domaines

Chimie

Fichier principal

Oger et al. Synthesis, 2018, 50, 3257-3280_HAL.pdf (1.2 Mo)

Origine : Fichiers produits par l'(les) auteur(s)

Mélanie KARLI : Connectez-vous pour contacter le contributeur

https://hal.umontpellier.fr/hal-02613521

Soumis le : jeudi 3 juin 2021-15:39:02

Dernière modification le : jeudi 11 avril 2024-13:08:13

Archivage à long terme le : samedi 4 septembre 2021-18:58:14

Dates et versions

hal-02613521 , version 1 (03-06-2021)

Identifiants

HAL Id : hal-02613521 , version 1
DOI : 10.1055/s-0036-1589540

Citer

Camille Oger, Claire Cuyamendous, Aurélien de La Torre, Mathieu Candy, Alexandre Guy, et al.. History of Chemical Routes towards Cyclic Non-Enzymatic Oxygenated Metabolites of Polyunsaturated Fatty Acids. Synthesis: Journal of Synthetic Organic Chemistry, 2018, 50 (17), pp.3257-3280. ⟨10.1055/s-0036-1589540⟩. ⟨hal-02613521⟩

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