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Article dans une revue

Cell-based therapy against prion diseases

Abstract : Despite multiple efforts to find treatments, prion diseases are still incurable. The currently available therapeutic strategies are mostly based on compounds to inhibit pathological PrP (PrPSc) accumulation, and cellular PrP (PrPC) conversion into PrPSc. However, they cannot reverse the pathological changes already present in the brain. Cell-based therapeutic strategies could promote the repair of the pre-existing brain damage. The few available data come mostly from preclinical studies using neural stem cells, bone marrow-derived microglia and mesenchymal stem cells, as cell sources. Moreover, the benefits of cell-based therapeutic strategies could be linked not only to the replacement of damaged cells, but also to the secretion of trophic factors by the grafted cells that might modulate inflammation, cell death, or endogenous neurogenesis.
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Contributeur : Amandine Michel-Avella <>
Soumis le : mardi 12 mai 2020 - 18:42:25
Dernière modification le : vendredi 15 mai 2020 - 12:22:10




Aroa Relaño-Ginès, Sylvain Lehmann, Carole Crozet. Cell-based therapy against prion diseases. Current Opinion in Pharmacology, Elsevier, 2019, 44, pp.8-14. ⟨10.1016/j.coph.2018.11.001⟩. ⟨hal-02571397⟩



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