Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Chromothripsis, a credible chromosomal mechanism in evolutionary process

Abstract : The recent discovery of a new class of massive chromosomal rearrangements, occurring during one unique cellular event and baptized "chromothripsis," deeply modifies our perception on the genesis of complex genomic rearrangements, but also, it raises the question of the potential driving role of chromothripsis in species evolution. Analyses of the etiology of chromothripsis have led to the identification of various cellular processes capable of generating chromothripsis, such as premature chromosome condensation, telomere dysfunction, abortive apoptosis, and micronucleus formation. All these causative mechanisms may occur in germlines or during early embryonic development, suggesting that chromothripsis could be an unexpected mechanism for profound genome modification. The occurrence of chromothripsis appears to be in good agreement with macroevolution models proposed as a complement to phyletic gradualism. Various cases of chromosomal speciation and short-term adaptation could be correlated to chromothripsis-mediated mechanism. The emergency of this unanticipated chaotic phenomenon may contribute to demonstrate the contribution of chromosome rearrangements to speciation process. New sequencing and bioinformatics methods can be expected to shed new light on the role of chromothripsis in evolutionary process.
Liste complète des métadonnées

https://hal.umontpellier.fr/hal-02553240
Contributeur : Amandine Michel-Avella <>
Soumis le : vendredi 24 avril 2020 - 11:33:44
Dernière modification le : vendredi 15 mai 2020 - 12:22:10

Identifiants

Collections

Citation

Franck Pellestor, Vincent Gatinois. Chromothripsis, a credible chromosomal mechanism in evolutionary process. Chromosoma, Springer Verlag, 2019, 128 (1), pp.1-6. ⟨10.1007/s00412-018-0679-4⟩. ⟨hal-02553240⟩

Partager

Métriques

Consultations de la notice

13