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Prognostic factors for the sequelae and severity of Guillain‐Barré syndrome in children

Abstract : Introduction: Guillain-Barré syndrome (GBS) is an inflammatory polyradiculoneuritis.Our aim in this study was to describe the clinical characteristics and the long-termsequelae of GBS in a French pediatric population.Methods: In this multicenter, retrospective study we evaluated clinical signs, radio-logical examinations, laboratory tests, treatments, and outcomes.Results: One hundred ten children were included in this investigation. These childrenpresented with walking difficulties, muscle weakness, and cranial nerve impairment.Electrodiagnostic testing revealed 70% with acute inflammatory demyelinating poly-radiculoneuropathy (AIDP) and 16% with acute motor axonal neuropathy (AMAN).One hundred children received immunoglobulins. At follow-up, 77% were cured,whereas 9% had sequelae, associated with an axonal form (P < .01) and a short inter-val between symptom onset and hospitalization (P < .01). The need for intubationwas correlated with peripheral facial paralysis (P < .01) and dysautonomia (P < .01).Discussion: Although AIDP and AMAN present in a similar way, the axonal form isassociated with a worse outcome.
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Soumis le : jeudi 16 avril 2020 - 10:43:54
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Sophie Estrade, Clara Guiomard, Vincent Fabry, Éloïse Baudou, Claude Cances, et al.. Prognostic factors for the sequelae and severity of Guillain‐Barré syndrome in children. Muscle & nerve. Supplement., 2019, 60 (6), pp.716-723. ⟨10.1002/mus.26706⟩. ⟨hal-02544255⟩



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