Preliminary evidence for a role of the adrenergic nervous system in generalized anxiety disorder

Abstract : Generalized anxiety disorder (GAD) is a common chronic condition that is understudied compared to other psychiatric disorders. An altered adrenergic function has been reported in GAD, however direct evidence for genetic susceptibility is missing. This study evaluated the associations of gene variants in adrenergic receptors (ADRs) with GAD, with the involvement of stressful events. Data were obtained from 844 French community-dwelling elderly aged 65 or over. Anxiety disorders were assessed using the Mini-International Neuropsychiatry Interview, according to DSM-IV criteria. Eight single-nucleotide polymorphisms (SNPs) involved with adrenergic function were genotyped; adrenergic receptors alpha(1A) (ADRA1A), alpha(2A) (ADRA2A), and beta2 (ADRB2) and transcription factor TCF7L2. Questionnaires evaluated recent stressful life events as well as early environment during childhood and adolescence. Using multivariate logistic regression analyses four SNPs were significantly associated with GAD. A 4-fold modified risk was found with ADRA1A rs17426222 and rs573514, and ADRB2 rs1042713 which remained significant after Bonferroni correction. Certain variants may moderate the effect of adverse life events on the risk of GAD. Replication in larger samples is needed due to the small case number. This is the first study showing that ADR variants are susceptibility factors for GAD, further highlighting the critical role of the adrenergic nervous system in this disorder.
Type de document :
Article dans une revue
Liste complète des métadonnées

Littérature citée [59 références]  Voir  Masquer  Télécharger

https://hal.umontpellier.fr/hal-02400516
Contributeur : Anthony Herrada <>
Soumis le : lundi 9 décembre 2019 - 15:13:19
Dernière modification le : mercredi 15 janvier 2020 - 09:20:03

Fichier

Ancelin_26.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Collections

Citation

Xiaobin Zhang, Joanna Norton, Isabelle Carrière, Karen Ritchie, Isabelle Chaudieu, et al.. Preliminary evidence for a role of the adrenergic nervous system in generalized anxiety disorder. Scientific Reports, Nature Publishing Group, 2017, 7, pp.42676. ⟨10.1038/srep42676⟩. ⟨hal-02400516⟩

Partager

Métriques

Consultations de la notice

14

Téléchargements de fichiers

20