Spatial Assessment of Contact Between Humans and Anopheles and Aedes Mosquitoes in a Medium-Sized African Urban Setting, Using Salivary Antibody-Based Biomarkers - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Journal of Infectious Diseases Année : 2019

Spatial Assessment of Contact Between Humans and Anopheles and Aedes Mosquitoes in a Medium-Sized African Urban Setting, Using Salivary Antibody-Based Biomarkers

Résumé

BACKGROUND: Anarchic and poorly controlled urbanization led to an increased risk of mosquito-borne diseases (MBD) in many African cities. Here, we evaluate the spatial heterogeneity of human exposure to malaria and arboviral disease vectors in an urban area of northern Senegal, using antibody-based biomarkers of exposure to Anopheles and Aedes mosquito bites.METHODS: A cross-sectional study was undertaken during the rainy season of 2014 in 4 neighborhoods of Saint-Louis, a city in northern Senegal. Among children aged 6-59 months in each neighborhood, the dried blood spot technique was used to evaluate immunoglobulin G (IgG) responses to both gSG6-P1 (Anopheles) and Nterm-34-kDa (Aedes) salivary peptides as validated biomarkers of respective mosquito bite exposure.RESULTS: IgG response levels to gSG6-P1 and Nterm-34-kDa salivary peptides varied significantly between the 4 neighborhoods (P < .0001). The level of exposure to Aedes bites also varied according to household access to sanitation services (P = .027), whereas that of exposure to Anopheles bites varied according to insecticide-treated bed net use (P = .006). In addition, spatial clusters of high contact between humans and mosquitoes were identified inside 3 neighborhoods.CONCLUSIONS: Antibody-based biomarkers of exposure to Anopheles and Aedes mosquito bites could be helpful tools for evaluating the heterogeneity of exposure to malaria and arboviral disease vectors by national control programs
Fichier principal
Vignette du fichier
Sagna et al 2019_Spatial assessment of Human-mosquitoes contact using Ab-based biomarkers.pdf (778.96 Ko) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-02389123 , version 1 (02-12-2019)

Identifiants

Citer

André Sagna, Daouda Kassié, Agnès Couvray, Akré Maurice Adja, Emmanuel Hermann, et al.. Spatial Assessment of Contact Between Humans and Anopheles and Aedes Mosquitoes in a Medium-Sized African Urban Setting, Using Salivary Antibody-Based Biomarkers. Journal of Infectious Diseases, 2019, 220 (7), pp.1199-1208. ⟨10.1093/infdis/jiz289⟩. ⟨hal-02389123⟩
243 Consultations
263 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More