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Article Dans Une Revue Journal of Clinical Medicine Année : 2017

Stromal Modulators of TGF-β in Cancer


Transforming growth factor-β (TGF-β) is an intriguing cytokine exhibiting dual activities in malignant disease. It is an important mediator of cancer invasion, metastasis and angiogenesis, on the one hand, while it exhibits anti-tumor functions on the other hand. Elucidating the precise role of TGF-β in malignant development and progression requires a better understanding of the molecular mechanisms involved in its tumor suppressor to tumor promoter switch. One important aspect of TGF-β function is its interaction with proteins within the tumor microenvironment. Several stromal proteins have the natural ability to interact and modulate TGF-β function. Understanding the complex interplay between the TGF-β signaling network and these stromal proteins may provide greater insight into the development of novel therapeutic strategies that target the TGF-β axis. The present review highlights our present understanding of how stroma modulates TGF-β activity in human cancers.


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hal-02371973 , version 1 (25-05-2021)



Brunella Costanza, Ijeoma Umelo, Justine Bellier, Vincent Castronovo, Andrei Turtoi. Stromal Modulators of TGF-β in Cancer. Journal of Clinical Medicine, 2017, 6 (1), pp.7. ⟨10.3390/jcm6010007⟩. ⟨hal-02371973⟩
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