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Evolved Dependence in Response to Cancer

Abstract : Evolved dependence is a process through which one species becomes 'dependent' on another following a long evolutionary history of interaction. This happens when adaptations selected in the first species for interacting lead to fitness costs when the second species is not encountered. Evolved dependence is frequent in host-parasite interactions, where hosts may achieve a higher fitness in the presence of the parasite than in its absence. Since oncogenic manifestations are (i) ubiquitous across multicellular life, (ii) involved in parasitic-like interactions with their hosts, and (iii) have effectively driven the selection of numerous adaptations, it is possible that multicellular organisms display evolved dependence in response to oncogenic processes. We provide a comprehensive overview of the topic, including the implications for cancer prevention and treatment.
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Contributeur : Anthony Herrada <>
Soumis le : mercredi 6 novembre 2019 - 14:06:17
Dernière modification le : jeudi 17 décembre 2020 - 18:02:04



Frédéric Thomas, Irina Kareva, Nynke Raven, Rodrigo Hamede, Pascal Pujol, et al.. Evolved Dependence in Response to Cancer. Trends in Ecology and Evolution, Elsevier, 2018, 33 (4), pp.269-276. ⟨10.1016/j.tree.2018.01.012⟩. ⟨hal-02351466⟩



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