Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization

Abstract : Mesoporous organosilica nanoparticles (PHT-PMO) have been prepared from an octa-triethoxysilylated Zn phthalocyanine precursor. These PHT-PMO nanoparticles had no dark toxicity but high phototoxicity when irradiated at 650 nm, and remarkable near-infrared phototoxicity when excited at 760 and 810 nm. The PHT-PMO were then aminated to promote electrostatic complexation with siRNA. Transfection experiments were performed upon NIR irradiation and photochemical internalization was very efficient, leading to 65% luciferase extinction in MCF-7 cancer cells expressing stable luciferase.
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https://hal.umontpellier.fr/hal-02315779
Contributeur : Odile Hennaut <>
Soumis le : lundi 14 octobre 2019 - 17:43:11
Dernière modification le : mardi 15 octobre 2019 - 01:22:45

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Gülçin Ekineker, Christophe Nguyen, Sümeyra Bayır, Sofia Dominguez Gil, Ümit Işci, et al.. Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization. Chemical Communications, Royal Society of Chemistry, 2019, 55 (77), pp.11619-11622. ⟨10.1039/c9cc05703j⟩. ⟨hal-02315779⟩

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