Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Chemical Communications Année : 2019

Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization

Fabienne Dumoulin

Résumé

Mesoporous organosilica nanoparticles (PHT-PMO) have been prepared from an octa-triethoxysilylated Zn phthalocyanine precursor. These PHT-PMO nanoparticles had no dark toxicity but high phototoxicity when irradiated at 650 nm, and remarkable near-infrared phototoxicity when excited at 760 and 810 nm. The PHT-PMO were then aminated to promote electrostatic complexation with siRNA. Transfection experiments were performed upon NIR irradiation and photochemical internalization was very efficient, leading to 65% luciferase extinction in MCF-7 cancer cells expressing stable luciferase.

Domaines

Chimie
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Dates et versions

hal-02315779 , version 1 (14-10-2019)

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Citer

Gülçin Ekineker, Christophe Nguyen, Sümeyra Bayir, Sofia Dominguez Gil, Ümit İşci, et al.. Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization. Chemical Communications, 2019, 55 (77), pp.11619-11622. ⟨10.1039/c9cc05703j⟩. ⟨hal-02315779⟩
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