Cancer bronchique à petites cellules et agent onco-immunologique : peut-on sortir de l’ère du tout cisplatine étoposide ? - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Revue des Maladies Respiratoires Année : 2018

Cancer bronchique à petites cellules et agent onco-immunologique : peut-on sortir de l’ère du tout cisplatine étoposide ?

[Small cell lung cancer and immuno-oncologic agents: End of the cisplatin - etoposide era?]

Résumé

In the setting of small cell lung cancer (SCLC), the development of immuno-oncological agents, particularly those targeting Programmed cell Death protein 1 (PD-1) and Programmed cell Death protein Ligand 1 (PD-L1), is still at an early stage. Two critical elements need to be considered : the current data are extracted from Phase I and Phase II trials and the level of evidence from phase III trials has not been reached as it has been for non-small cell lung cancer (NSCLC) or for malignant melanoma ; The second aspect is the slow development of predictive factors for response to the immuno-oncological agents targeting the PD-1 receptor and its ligand. The clinical data are still too fragmentary to produce recommendations, although the improvement in progression-free survival seen in different phase II studies is promising. The expectation of clinicians dealing withSCLC is an indication of the challenge that this disease currently poses to oncology and justifies a focused clinical research effort.
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Dates et versions

hal-02315296 , version 1 (14-10-2019)

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Citer

J.L. Pujol, B. Roch. Cancer bronchique à petites cellules et agent onco-immunologique : peut-on sortir de l’ère du tout cisplatine étoposide ?. Revue des Maladies Respiratoires, 2018, 35 (8), pp.846-851. ⟨10.1016/j.rmr.2017.07.026⟩. ⟨hal-02315296⟩
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