 |
Article dans une revue
Examination of HER3 targeting in cancer using monoclonal antibodies
Abstract : The human EGF receptor (HER/EGFR) family of receptor tyrosine kinases serves as a key target for cancer therapy. Specifically, EGFR and HER2 have been repeatedly targeted because of their genetic aberrations in tumors. The therapeutic potential of targeting HER3 has long been underestimated, due to relatively low expression in tumors and impaired kinase activity. Nevertheless, in addition to serving as a dimerization partner of EGFR and HER2, HER3 acts as a key player in tumor cells' ability to acquire resistance to cancer drugs. In this study, we generated several monoclonal antibodies to HER3. Comparisons of their ability to degrade HER3, decrease downstream signaling, and inhibit growth of cultured cells, as well as recruit immune effector cells, selected an antibody that later emerged as the most potent inhibitor of pancreatic cancer cells grown as tumors in animals. Our data predict that anti-HER3 antibodies able to intercept autocrine and stroma-tumor interactions might strongly inhibit tumor growth, in analogy to the mechanism of action of anti-EGFR antibodies routinely used now to treat colorectal cancer patients.
Littérature citée [47 références]
https://hal.umontpellier.fr/hal-02276327
Contributeur : Mélanie Karli <>
Soumis le : lundi 2 septembre 2019 - 16:04:03
Dernière modification le : jeudi 15 octobre 2020 - 14:42:04
Archivage à long terme le : : jeudi 9 janvier 2020 - 06:16:32
Contributeur : Mélanie Karli <>
Soumis le : lundi 2 septembre 2019 - 16:04:03
Dernière modification le : jeudi 15 octobre 2020 - 14:42:04
Archivage à long terme le : : jeudi 9 janvier 2020 - 06:16:32
Fichier
pnas.201423645.pdf
Fichiers éditeurs autorisés sur une archive ouverte
Licence
Distributed under a Creative Commons Paternité - Pas d'utilisation commerciale 4.0 International License