TRIM28 represses transcription of endogenous retroviruses in neural progenitor cells. - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Cell Reports Année : 2015

TRIM28 represses transcription of endogenous retroviruses in neural progenitor cells.

Résumé

TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. We find that NPCs use TRIM28-mediated histone modifications to dynamically regulate transcription and silencing of ERVs, which is in contrast to other somatic cell types using DNA methylation. We also show that derepression of ERVs influences transcriptional dynamics in NPCs through the activation of nearby genes and the expression of long noncoding RNAs. These findings demonstrate a unique dynamic transcriptional regulation of ERVs in NPCs. Our results warrant future studies on the role of ERVs in the healthy and diseased brain.
Fichier principal
Vignette du fichier
emss-63292.pdf (1.11 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02275990 , version 1 (02-09-2019)

Identifiants

Citer

Liana Fasching, Adamandia Kapopoulou, Rohit Sachdeva, Rebecca Petri, Marie E. Jönsson, et al.. TRIM28 represses transcription of endogenous retroviruses in neural progenitor cells.. Cell Reports, 2015, 10 (1), pp.20-28. ⟨10.1016/j.celrep.2014.12.004⟩. ⟨hal-02275990⟩
135 Consultations
115 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More