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From enabling technologies to medicinal mechanochemistry: an eco-friendly access to hydantoin-based active pharmaceutical ingredients

Evelina Colacino 1 Andrea Porcheddu 2, 3 Clarence Charnay 1 Francesco Delogu 2, 4
1 ICGM ICMMM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
2 Universita degli Studi di Cagliari [Cagliari]
3 Dipartimento di Scienze Chimiche e Geologiche Centro Grandi Strumenti and INSTM unit
4 Dipartimento di Ingegneria Meccanica
Abstract : The preparation of hydantoin scaffolds using modern non-conventional activation methods is herein described. Special attention is devoted to the preparation of hydantoin-based Active Pharmaceutical Ingredients (APIs) by mechanochemistry, highlighting its advantages compared to classical solution procedures, opening new perspectives in the sustainable preparation of useful scaffolds for the pharmaceutical industry.
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https://hal.umontpellier.fr/hal-02272827
Contributeur : Odile Hennaut <>
Soumis le : mercredi 28 août 2019 - 11:07:14
Dernière modification le : jeudi 29 août 2019 - 01:16:49

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UNIV-MONTPELLIER | CNRS | INC-CNRS | CHIMIE | ICG

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Evelina Colacino, Andrea Porcheddu, Clarence Charnay, Francesco Delogu. From enabling technologies to medicinal mechanochemistry: an eco-friendly access to hydantoin-based active pharmaceutical ingredients. Reaction Chemistry & Engineering, Royal Society of Chemistry, 2019, 4 (7), pp.1179-1188. ⟨10.1039/c9re00069k⟩. ⟨hal-02272827⟩

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