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[Breast cancer: radiotherapy and estrogen signaling]

Abstract : Hormone receptors are expressed in more than 75% of breast cancer. Therefore, two prescription modalities of endocrine therapy could be proposed: either sequential or concomitant to breast cancer irradiation. If combined to radiotherapy, is endocrine therapy a radiosensitizer? Does endocrine therapy enhance the risk factor of radio-induced toxicity? Here, we will distinguish the interaction of ionizing radiation combined with therapies targeting oestrogen receptor (REalpha) from the interaction of ionizing radiation with oestrogen. This review aims at making clear all these items.
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Contributeur : Cécile Nowak <>
Soumis le : vendredi 28 juin 2019 - 13:49:22
Dernière modification le : mercredi 14 août 2019 - 16:08:13




Céline Bourgier, Claire Lemanski, Gilles Romieu, M. Ozsahin, David Azria. [Breast cancer: radiotherapy and estrogen signaling]. Bulletin du Cancer, John Libbey Eurotext, 2014, 101, pp.714--7. ⟨10.1684/bdc.2014.1954⟩. ⟨hal-02168049⟩



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