[Breast cancer: radiotherapy and estrogen signaling]
Résumé
Hormone receptors are expressed in more than 75% of breast cancer. Therefore, two prescription modalities of endocrine therapy could be proposed: either sequential or concomitant to breast cancer irradiation. If combined to radiotherapy, is endocrine therapy a radiosensitizer? Does endocrine therapy enhance the risk factor of radio-induced toxicity? Here, we will distinguish the interaction of ionizing radiation combined with therapies targeting oestrogen receptor (REalpha) from the interaction of ionizing radiation with oestrogen. This review aims at making clear all these items.
Mots clés
Humans
Female
Treatment Outcome
Signal Transduction
Randomized Controlled Trials as Topic
didactique
Antineoplastic Agents
Hormonal/*therapeutic use
Breast Neoplasms/*metabolism/*therapy
Chemoradiotherapy/*methods
Estradiol/analogs & derivatives/therapeutic use
Estrogens/*metabolism
Molecular Targeted Therapy/methods
Radiation Pneumonitis/etiology
Receptors
Estrogen/*metabolism
Tamoxifen/*therapeutic use