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Case definition and classification of leukodystrophies and leukoencephalopathies

Abstract : OBJECTIVE: An approved definition of the term leukodystrophy does not currently exist. The lack of a precise case definition hampers efforts to study the epidemiology and the relevance of genetic white matter disorders to public health. METHOD: Thirteen experts at multiple institutions participated in iterative consensus building surveys to achieve definition and classification of disorders as leukodystrophies using a modified Delphi approach. RESULTS: A case definition for the leukodystrophies was achieved, and a total of 30 disorders were classified under this definition. In addition, a separate set of disorders with heritable white matter abnormalities but not meeting criteria for leukodystrophy, due to presumed primary neuronal involvement and prominent systemic manifestations, was classified as genetic leukoencephalopathies (gLE). INTERPRETATION: A case definition of leukodystrophies and classification of heritable white matter disorders will permit more detailed epidemiologic studies of these disorders.
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Contributeur : Anthony Herrada <>
Soumis le : lundi 13 mai 2019 - 09:50:09
Dernière modification le : vendredi 27 mars 2020 - 02:53:46

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Adeline Vanderver, Morgan Prust, Davide Tonduti, Fanny Mochel, Heather Hussey, et al.. Case definition and classification of leukodystrophies and leukoencephalopathies. Molecular Genetics and Metabolism, Elsevier, 2015, 114 (4), pp.494-500. ⟨10.1016/j.ymgme.2015.01.006⟩. ⟨hal-02126956⟩



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